Pleiotropic cellular effects of leptin
- 1 April 1999
- journal article
- diabetes and-the-endocrine-pancreas
- Published by Wolters Kluwer Health in Current Opinion in Endocrinology, Diabetes and Obesity
- Vol. 6 (2) , 163-169
- https://doi.org/10.1097/00060793-199904000-00013
Abstract
The discovery of the ob gene and leptin heralded a new beginning in our understanding of neuroendocrine mechanisms regulating food intake and body composition. However, in addition to rapid progress in these areas of research, functions for leptin outside of the regulation of body energy stores have been observed. The continuing discovery of novel leptin actions suggests that leptin should be considered as more than just an “antiobesity” hormone.Keywords
This publication has 82 references indexed in Scilit:
- Effects of leptin on insulin secretion from isolated rat pancreatic isletsDiabetes, 1998
- Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosaThe Journal of Pediatrics, 1997
- Leptin Induces Proliferation of Pancreatic β Cell Line MIN6 through Activation of Mitogen-Activated Protein KinaseBiochemical and Biophysical Research Communications, 1997
- Increase of Mouse Leptin Production by Adipose Tissue after Midpregnancy: Gestational Profile of Serum Leptin ConcentrationBiochemical and Biophysical Research Communications, 1997
- The Placenta Is Not the Main Source of Leptin Production in Pregnant Rat: Gestational Profile of Leptin in Plasma and Adipose TissuesBiochemical and Biophysical Research Communications, 1997
- Leptin Is Present in Human Milk and Is Related to Maternal Plasma Leptin Concentration and AdiposityBiochemical and Biophysical Research Communications, 1997
- Leptin Inhibits Insulin Secretion and Reduces Insulin mRNA Levels in Rat Isolated Pancreatic IsletsBiochemical and Biophysical Research Communications, 1997
- Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.Journal of Clinical Investigation, 1997
- Do Leptin Receptors Play a Functional Role in the Endocrine Pancreas?Biochemical and Biophysical Research Communications, 1996
- Abnormal splicing of the leptin receptor in diabetic miceNature, 1996