Uptake of Propranolol by the Lung and Its Displacement by Other Drugs: Involvement of the Alveolar Macrophage
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 20 (5) , 275-283
- https://doi.org/10.1159/000137373
Abstract
The role of the alveolar macrophage in the uptake of 3H-propranolol by the isolated perfused rabbit lung and displacement of 3H-propranolol from this site has been investigated. Removal of 3H-propranolol (100 µg) by the lung was characterized by a rapid distribution phase (t1/2 = 2 min) and a slower elimination phase with a clearance of 22.4 ml/min (t½ = 47 min). Addition of chlorpromazine (1 mg) at 30 min was followed by a twofold increase in perfusate concentrations of 3H-propranolol which was also associated with a reduction of 3H-propranolol in macrophages recovered from lungs at the end of perfusion experiments. Experiments using isolated alveolar macrophages demonstrated uptake of propranolol and marked inhibition by 100-fold higher concentrations of chlorpromazine and imipramine. In the intact dog, injection of imipramine (1 mg/kg) 60–70 min after bolus injection of 3H-propranolol (0.3 mg/kg) was associated with an immediate increase in blood levels of 3H-propranolol consistent with tissue redistribution. It is concluded that chlorpromazine and imipramine can displace propranolol from the lung, and that the alveolar macrophage is involved in this process.This publication has 2 references indexed in Scilit:
- COMPARISON OF SOME PROPERTIES OF PRONETHALOL AND PROPRANOLOLBritish Journal of Pharmacology and Chemotherapy, 1965
- PHYSIOLOGICAL DISPOSITION AND FATE OF CHLORPROMAZINE AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIAL1956