ON THE EFFECT OF ATHEROSCLEROSIS AND GOITRE ON AORTIC HISTOPATHOLOGY AND MUCOPOLYSACCHARIDE CONTENT

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Abstract
The effect of goitre on aortic mucopolysaccharides in sclerotic and nonsclerotic subjects was studied by histological and biochemical methods. Atherosclerosis alone lowers the quantity of aortic acid mucopolysaccharides. Goitre alone shows a tendency to increase the mucopolysaccharide content of the aorta. Goitre accelerates the effect of atherosclerosis in decreasing the aortic mucopolysaccharides, i.e. fibrosing and sclerosing effect. Histological observations reveal that atherosclerosis is characterized, in all groups, by fatty degeneration of intima and inner elastic membrane and destruction of the elastic connective tissue, and in the process of repair the mucopolysaccharides increase. In connection with the ensuing collagenization, the mucopolysaccharides decrease. It is suggested that goitre by hypo- or hyper-function causes metabolic disturbances in the aortic wall and thus promotes atherosclerosis.

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