Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses.
Open Access
- 1 February 1984
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 132 (2) , 979-984
- https://doi.org/10.4049/jimmunol.132.2.979
Abstract
The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.Keywords
This publication has 0 references indexed in Scilit: