Application of Mutagenicity Test for Milk

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Abstract
Mutagenic activity in milk and milk products was tested by the Salmonella typhimurium mammalian microsome mutagenicity test (Ames test). S. typhimurium strains susceptible to base-pair substitution and frameshift mutagens gave positive results with heat-sterilized milk, particularly after activation by the S-9 fraction of microsomes. Maximum increase of His+ revertants was more than twice the spontaneous increase. The chemical specification of the mutagenic activity was not yet defined, but it was present in the chloroform extract of milk. [Human applicability of this study is discussed].

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