Calcium kinetics in the aorta of spontaneously hypertensive rats
- 1 July 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 11 (4) , 353-357
- https://doi.org/10.1093/cvr/11.4.353
Abstract
In the search for abnormalities in hypertensive vessels Ca kinetics was studied in the aorta of spontaneously hypertensive rats (SHR). The uptake of 45Ca was significantly less in hypertensive animals but the uptake of ‘Lanthanum resistant’ 45Ca was not. The efflux of 45Ca from aorta of SHR was different (P<0.01) from that of control rats because of faster initial efflux. The half-life of the first 2 components of efflux curves was significantly shorter in SHR. Results are interpreted as consequences of decreased Ca binding by smooth muscle membrane in hypertensive vessels.Keywords
This publication has 1 reference indexed in Scilit:
- Participation of Neural Factor in the Pathogenesis of Hypertension in the Spontaneously Hypertensive RatJapanese Heart Journal, 1967