THE EFFECTS OF PARATHYROID HORMONE ON SERUM GLYCOPROTEIN AND SEROMUCOID LEVELS AND ON THE KIDNEY OF THE RAT1

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Abstract
Following the administration for 3 days of parathyroid extract with hypercalcemic activity both serum glycoprotein and seromucoid were elevated. Kidney lesions were noted by histological examination; these areas contained Ca and gave staining reactions for polysaccharides. Administration of parathyroid extract treated with formaldehyde had no significant effects on serum Ca and serum glycoprotein, and did not cause kidney damage; however, it resulted in a striking elevation of seromucoid. Parathyroid extract treated with pepsin, bovine gamma-globulin alone, or bovine gamma-globulin treated with formaldehyde had no significant effects on serum glycoprotein, seromucoid or serum Ca. It is concluded that parathyroid extract affects seromucoid independently of its action on serum Ca.