Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface
- 15 September 1983
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 214 (3) , 777-784
- https://doi.org/10.1042/bj2140777
Abstract
Binding of exogenous [35S]sulphate-labelled cartilage proteoglycans to cells was studied with suspension cultures of calf articular-cartilage chondrocytes. Proteoglycans interact with hyaluronic acid at the cell surface via their hyaluronic acid-binding region. The binding is time-dependent and saturable, but does not appear to be freely reversible. The bound 35S-labelled proteoglycans are located at the cell surface, and only small proportions of the proteoglycans are internalized.This publication has 23 references indexed in Scilit:
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