The Development of a Disease-Specific Questionnaire to Assess Quality of Life for Psoriasis Patients: An Analysis of the Reliability, Validity, and Responsiveness of the Psoriasis Quality of Life Questionnaire

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Abstract
Background: The Psoriasis Quality of Life (PQOL) questionnaire was developed based on a US-wide epidemiologically balanced population of psoriasis patients to assess quality of life. Objective: A shortened form of the PQOL questionnaire was used in a clinical trial to assess its reliability, validity, and responsiveness. Methods: The PQOL questionnaire contains 41 items in two domains (psychosocial and physical). 71 psoriasis patients rated each item from 0 (best health state) to 10 (worst health state) before and after topical treatment. Results: When measuring reliability, there was a high correlation of items with their total domain scores. In terms of validity, there were fairly large variations among means and variances for items in both domains. Most items contributed roughly equal proportions to the total domain score. In regard to responsiveness, values spanned 88% and 81% of the possible response ranges for the psychosocial and physical domains, respectively, being consistent with a broad span of response. There was a lack of floor or ceiling effects, with no domain scores at or beyond the minimum or maximum ends of the spectrum. Additionally, values spanned the range for both domains. Conclusion: The statistical analysis supports reasonable reliability, validity, and responsiveness of the PQOL questionnaire. The questionnaire could be optimized by administration to a larger group with broader disease severity.

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