The role of CA 125 in the early diagnosis of progressive disease in ovarian cancer

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Abstract
The role of CA 125 determination in diagnosing progression of ovarian cancer was evluated in 98 patients of whom forty-nine had progressive disease. An elevated CA 125 level at the time of progression was found in 36 (73%) patients. In 31(63%) patients CA 125 increase preceded clinical progression for a median time lag of 4.5 months (range 0.5–29.5 months). The combination of seram CA 125, gynecological and general physical examination detected progression in 45 (92%) patients. The additional contribution of second-look surgely, CTscan, chest X-ray and routine laboratory tests was minimal.