Heterozygous Beta Thalassemia: Balanced Globin Synthesis in Bone Marrow Cells
- 13 March 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3924) , 1513-1514
- https://doi.org/10.1126/science.167.3924.1513
Abstract
In two patients with heterozygous beta thalassemia the rates of synthesis of the alpha and beta chains of hemoglobin were equal in nucleated red cell precursors, although beta chain synthesis was reduced in peripheral blood reticulocytes. This finding suggests a relative instability of beta chain messenger RNA in beta thalassemia.Keywords
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