Antilymphocyte Serum and Tissue Culture Used to Investigate Role of Cell-mediated Response in Viral Encephalitis in Mice
- 24 October 1970
- Vol. 4 (5729) , 210-212
- https://doi.org/10.1136/bmj.4.5729.210
Abstract
Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.Keywords
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