CLINICAL OBSERVATIONS ON THE USE OF HYALURONIDASE

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Abstract
The use of hyaluronidase was observed in 116 infants and children in such procedures as hypodermoclysis, phthalein excretion test and urography. Eight tenths of a milligram (0.8 mg.) of the dry substance dissolved in 1 ml. of distilled water was used as a standard amount of the enzyme for all procedures. Hyaluronidase provided an effective expedient to fluid diffusion in subcutaneous therapy. From clinical observations, the speed of flow in any one case is dependent upon: 1. general development of the patient, 2. state of hydration of the patient, 3. activity of the patient, 4. position of the needles in the skin, 5. original speed of the flow and 6. type and amount of fluid given. There was no significant change either in dye excretion or total renal fluid excretion when hyaluronidase was used in the phthalein excretion test. Hyaluronidase reduced the amount of dye necessary when given subcutaneously to secure adequate visualization in urography. Repeated urinalyses in many of the procedures showed no evidence of renal pathology. There were no instances of thermal reaction, spread of infection, or reactivation of infection that could be attributed to the use of the enzyme.