Pathogenesis of Viral Infections of the Nervous System

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Abstract
Crossing from Blood to BrainA variety of mechanisms involving both blood–cerebrospinal-fluid–brain and more direct blood–brain pathways have been postulated to explain how viruses negotiate the cells and membranes separating the blood from susceptible cells in the brain.Virus in the blood might enter the cerebrospinal fluid by either passing or growing through the choroid plexus. Capillaries within the choroid plexes have been shown to have porous endothelium65 and to be surrounded by a loose stroma of connective tissue.66 In both these respects they differ from capillaries within the parenchyma of the brain. Pappas and Tennyson65 injected colloidal particles intravenously . . .