Effectiveness of Boronated Tetracycline Antibiotic Derivatives (T2B2) as the Boron-10 Carrier in Neutron Capture Therapy
- 1 January 1973
- journal article
- Published by S. Karger AG in Oncology
- Vol. 27 (2) , 97-104
- https://doi.org/10.1159/000224724
Abstract
Commercially available transplantable adenocarcinoma (T1703) in Jackson Laboratory mice (DBA/1J) were studied using T2B2 to carry 105B for 105B thermal neutron capture therapy. The UCLA thermal neutron fluence was 2.7 × 10121₀n/cm2 and exposure was total body. There were no signs of typical radiation damage to skin, gastrointestinal tract, or hematopoietic system. The results indicated a significant (p= < 0.01) increase in mean survival of 15.85 days between T2B2 and Tc controls. Retardation in neoplastic growth was observed, and apparent permanent regression was achieved in 22.7% of the T2B2-treated animals.Keywords
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