CARDIOVASCULAR EFFECTS OF ETOMIDATE WITH EMPHASIS ON REGIONAL MYOCARDIAL BLOOD FLOW AND PERFORMANCE
Open Access
- 1 June 1981
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 53 (6) , 591-599
- https://doi.org/10.1093/bja/53.6.591
Abstract
The effects of 30-min infusions of etomidate 0.03, 0.06, 0.12 and 0.24 mg kg−1 min−1 on systemic and regional haemodynamic variables and cardiac performance and metabolism were studied in pigs. The drug caused moderate, but dose-dependent, decreases in the cardiac output, arterial pressure and LV dP/dt max. Myocardial wall thickening, measured by echographic analysis, was decreased by the drug. However, heart rate, myocardial blood flow distribution and myocardial metabolism of lactate, glucose and free fatty acids remained unchanged. Cerebral blood flow was decreased substantially. However, renal blood flow changed only slightly.Keywords
This publication has 1 reference indexed in Scilit:
- AN INVESTIGATION OF THE CENTRALLY AND PERIPHERALLY MEDIATED CARDIOVASCULAR EFFECTS OF ETOMIDATE IN THE RABBITBritish Journal of Anaesthesia, 1978