STEREOSELECTIVE SYNTHESIS OF CIS-α,β-EPOXYKETONES VIA DIVALENT TIN ENOLATE
- 5 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 11 (10) , 1601-1604
- https://doi.org/10.1246/cl.1982.1601
Abstract
A convenient method for the stereoselective synthesis of cis-β-substituted-α,β-epoxyketone is established employing Sn(OTf)2 mediated cross aldol reaction between α-bromoketone and aldehyde followed by successive treatment of the adduct with KF-dicyclohexyl-18-crown-6.Keywords
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