Molecular basis of enzyme catalysis and control

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Abstract
Regulatory processes in living systems can be shown to be caused by ligand induced changes in the shape of a protein. By dividing the protein shape changes into molecular parameters a quantitative analysis of the regulation process can be obtained which is shown to correlate with actual data in living systems. The complexity of the analysis increases as the number of subunits in the enzyme and the number of ligands considered in the regulatory proces in- creases. However, the principles are seen to be fundamentally similar in all cases. The orientation of reaction orbitals may be a key factor in the catalytic power of enzymes and in its regulatory control features.

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