Inactivation with Fast Charged Particles of Infectivity and Hemagglutination in Influenza A Virus

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Abstract
Two strains of influenza A, MEL and DSP, were subjected to bombardment in the dry state with charged particles of energies 1 to 8 mev. Target theory is applied to the resulting inactivations. In all cases, these are found to be single-hit. In the case of MEL the effect of bombardment with deuterons and alpha-particles of varying rates of energy loss shows the presence of 2 regions, one of high sensitivity and one of much lower sensitivity, the radii being 246 and 346 A, respectively. This last is slightly smaller than the values found in electron micrographs. The insensitive region is probably to be identified with lipid. For both strains, the hemagglutinin is a flat target, of axial ratio 1:6, and with an equivalent molecular weight of 190,000. This hemagglutinin is quite radiation-resistant, showing a requirement of at least 3 ion pairs per particle for inactivation.

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