Tryptophan Operon: Structural Gene Mutation Creating a "Promoter" and Leading to 5-Methyltryptophan Dependence
- 26 June 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3939) , 1586-1589
- https://doi.org/10.1126/science.168.3939.1586
Abstract
A strain carrying the mutation trpA515, which maps in the "unusual" region (between the genes trpA and trpB) of the tryptophan operon of Salmonella typhimurium is capable of utilizing anthranilic acid as a growth factor only in the presence of the analog 5-methyltryptophan, normally a potent growth inhibitor. The reason for this peculiar phenotype is the creation by trpA515 of a transcription-initiating signal in the "unusual" region.Keywords
This publication has 24 references indexed in Scilit:
- A mechanism for repressor actionJournal of Molecular Biology, 1969
- A transcription-initiating mutation within a structural gene of the tryptophan operonJournal of Molecular Biology, 1969
- Mutations caused by the insertion of genetic material into the galactose operon of Escherichia coliJournal of Molecular Biology, 1969
- Operator mutants of the tryptophan operon in Escherichia coliJournal of Molecular Biology, 1969
- A mutation which creates a new site for the re-initiation of polypeptide synthesis in the z gene of the lac operon of Escherichia coliJournal of Molecular Biology, 1968
- The promoter-operator region of the Lac operon of Escherichia coliJournal of Molecular Biology, 1968
- Product inhibition of anthranilate synthetase in Salmonella typhimuriumBiochemical and Biophysical Research Communications, 1968
- Mutations creating a new initiation point for expression of the histidine operon in Salmonella typhimuriumJournal of Molecular Biology, 1968
- Transcription of the tryptophan operon in polarity mutants of Escherichia coliJournal of Molecular Biology, 1967
- A mutant which reinitiates the polypeptide chain after chain terminationJournal of Molecular Biology, 1967