An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity

This publication has 17 references indexed in Scilit:

• Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail
  British Journal of Pharmacology, 2002
• Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner
  Anesthesia & Analgesia, 2001
• Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives
  British Journal of Pharmacology, 2001
• Succinylcholine Metabolite Succinic Acid Alters Steady State Activation in Muscle Sodium Channels
  Anesthesiology, 2000
• Structural Determinants of Slow Inactivation in Human Cardiac and Skeletal Muscle Sodium Channels
  Biophysical Journal, 1999
• Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors
  British Journal of Pharmacology, 1998
• Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.
  Journal of Clinical Investigation, 1996
• Functional consequences of lidocaine binding to slow-inactivated sodium channels.
  The Journal of general physiology, 1996
• Na+ channels must deactivate to recover from inactivation
  Neuron, 1994
• Lidocaine block of cardiac sodium channels.
  The Journal of general physiology, 1983