Repeated administration of subconvulsant doses of GABA antagonist drugs
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 76 (1) , 88-91
- https://doi.org/10.1007/bf00430763
Abstract
The effect on monoamine-mediated behaviour of repeated daily subconvulsive doses of the GABA antagonist drugs pentylenetetrazol (PTZ) (30 mg/kg for 8 days), picrotoxin (5 mg/kg for 4 days) and bicuculline (3.5 mg/kg for 16 days) was investigated. None of the drugs, administered chronically, increased behavioural responses to the 5-hydroxytryptamine agonist quipazine (25 mg/kg), and neither picrotoxin nor bicuculline altered the locomotor response to the dopamine agonist apomorphine (AP) (0.1 mg/kg). By contrast, repeated doses of PTZ increased the locomotor response to AP, and also increased circling responses to both AP (0.5 mg/kg) and methamphetamine (2.0 mg/kg) in unilateral nigrostriatal-lesioned rats.This publication has 27 references indexed in Scilit:
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