Localization of Bile Salt Absorption In Vivo in the Rabbit

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Abstract
Bile salt absorption was studied in a chronic, long-term rabbit preparation utilizing total biliary fistulas and surgical bypass of various segments of the intestinal tract. Bile salt absorption was determined from the bile radioactivity subsequent to a force-fed oral test dose of cholate-4-c14. In the rabbit the entire small intestinal tract and the colon (at least the cecum) are capable of absorbing cholate. There is, however, relatively small intestinal localization of cholate absorption to the ileum in comparison to the absorption in the jejunum. These findings are contrary to the prevalent concept that bile salts are absorbed exclusively in the ileum. The previous literature was reviewed.