Anti β2 glycoprotein I antibodies: detection and association with thrombosis

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Abstract
Summary. It has been demonstrated that antiphospholipid antibodies (aPL) recognize epitopes formed by anionic phospholipids and protein cofactors. β2 glycoprotein I (β2GPI) is accepted as the cofactor of anticardiolipin antibodies (aCL). In the present study we explored the presence and clinical associations of anti β2GPI antibodies of IgG isotype (aβ2GPI-IgG), measured by ELISA. We studied sera from 169 patients with aCL and/or lupus anticoagulant (LA), including 52 patients with systemic lupus erythematosus and 49 with primary antiphospholipid syndrome (PAPS). We found 31.9% positive sera for aβGPI-IgG in the whole population and 48.6% in the aCL-IgG(+) group. There was a good correlation between the titre of aCL-IgG and the optical density for aβGPI-IgG (r= 0.69, P 2GPI-IgG was associated with the presence of aCL-IgG (P P 2GPI-IgG. We found a statistically significant association between the presence of aβ2GPI-IgG and a history of venous thromboembolism (VTE) in our patients (P P 2GPI in special experimental conditions. In addition, the presence of these antibodies is associated with a history of VTE.