Two Phenomena Associated With Skin Grafting From Tumor-Bearing Syngeneic Donors

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Abstract
Syngeneic skin grafting from mice with transplantable solid tumors was often accompanied by the development of tumors originating from the skin grafts. These tumors appeared at intervals corresponding to the time of their development when pieces of tumors were transplanted. Syngeneic grafting of skin from mice with transplantable sarcoma resulted in the regular rejection of transplants. The presence of some tumors may cause the donor's tissues to become incompatible in the syngeneic system. The characteristics of this phenomenon, designated as “heterogenization” of skin by means of tumor, are presented. Skin grafts taken from mice that had rejected a skin transplant derived from a tumor-bearing donor were also rejected in the syngeneic transplantation. Possible mechanisms of the described phenomena are briefly discussed.

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