Fractionation of membrane proteins on phenylboronic acid-agarose

Abstract
Detergent-solubilized plasma membrane proteins from lymphocytes of patients with chronic lymphocytic leukemia were applied to phenylboronic acid-agarose. Some of the polypeptides were bound specifically and subsequently eluted with sorbitol. Immunoprecipitation analyses showed that no surface IgM was bound, but that most of the histocompatibility antigens HLA-A, HLA-B, HLA-C and HLA-DR were bound.