Adenosine 3′,5′-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release
- 9 February 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4073) , 569-571
- https://doi.org/10.1126/science.179.4073.569
Abstract
Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3',5'-monophosphate. If values for adenosine 3',5'-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3',5'-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.Keywords
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