Automatic chromosome analysis
- 1 March 1980
- journal article
- Published by Wiley in Clinical Genetics
- Vol. 17 (3) , 183-190
- https://doi.org/10.1111/j.1399-0004.1980.tb00131.x
Abstract
This paper describes an approach to the automatic analysis of banded B‐ and D‐group chromosomes, represented by band transition sequences (BT‐sequences), using Bayes formula in a simple way. The analysis considers the 14 BT‐codes constituting the BT‐sequence as being independent variables. Error rates of 6–8 % in classification experiments and 3–4 % in karyotyping experiments are clearly smaller than those reported by other authors using other methods. If the error rates of karyotyping are adjusted for errors in the basic material, they are reduced to 2–3 %. The reason for the small error rate is presumably that the BT‐sequences are superior to other methods for condensed band‐pattern description. The method will be incorporated into a programme system for automatic karyotyping.Keywords
This publication has 7 references indexed in Scilit:
- Microphotometry of banded human chromosomes IIIClinical Genetics, 2008
- Description of chromosome banding patterns by band transition sequencesClinical Genetics, 1979
- Visual classification of banded human chromosomesClinical Genetics, 1979
- Visual classification of banded human chromosomes: II. Classification and karyotyping of integrated density profilesAnnals of Human Genetics, 1977
- Visual classification of banded human chromosomes I. Karyotyping compared with classification of isolated chromosomesAnnals of Human Genetics, 1976
- Identification of Human Chromosomes by Using Integrated Density ProfilesIEEE Transactions on Biomedical Engineering, 1976
- Microphotometry of banded human chromosomes II:Technique for microphotography of banding patternsClinical Genetics, 1976