Evaluation of 1H-Magnetic Resonance Spectroscopy of Breast Cancer Pre- and Postgadolinium Administration

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Abstract
We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements. Single-voxel, proton spectroscopy measurements were obtained before and after the administration of gadolinium on 15 patients with ≥1-cm breast cancers. The protocol was repeated on a separate day in 7 patients. Postcontrast spectra demonstrated a significant increase in choline peak linewidth (day 1: 15% ± 21%, P = 0.03; day 2: 19% ± 12%, P = 0.001) and decrease in choline peak area (day 1: 11% ± 9% (P P Contrast administration caused significant increases in choline peak linewidth and decreases in choline peak area in spectroscopic measurements of breast cancer.