Pharmacokinetics of Cefaclor in Normal Subjects and Patients with Chronic Renal Failure
- 1 December 1977
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 12 (6) , 730-732
- https://doi.org/10.1128/aac.12.6.730
Abstract
We studied the pharmacokinetics of cefaclor, a new cephalosporin antibiotic, in normal subjects and subjects with chronic renal failure. Cefaclor was largely, but not entirely, eliminated by the kidneys. The cefaclor half-life in normal subjects was 40 to 60 min; in subjects with essentially no renal function, it increased to 3 h. In normal subjects, 50 to 70% of a 250-mg dose was excreted in the urine within 8 h. The linear relationship between the elimination constant and creatinine clearance allowed the construction of a useful dosage modification nomogram.Keywords
This publication has 5 references indexed in Scilit:
- Pharmacokinetics in renal diseaseThe American Journal of Medicine, 1977
- Antimicrobial dosage in renal failure: a unifying nomogram.1977
- Metabolism of [ 14 C]Cefaclor, a Cephalosporin Antibiotic, in Three Species of Laboratory AnimalsAntimicrobial Agents and Chemotherapy, 1976
- Rapid Detection of Ampicillin-Resistant Haemophilus influenzae and Their Susceptibility to Sixteen AntibioticsAntimicrobial Agents and Chemotherapy, 1975
- Determination of creatinine in small quantities of plasma. Observations on two methods.1960