Epigenetic Silencing of theCIITAGene and Posttranscriptional Regulation of Class II MHC Genes in Ocular Melanoma Cells

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Abstract
Purpose. Primary uveal melanocytes and many ocular melanoma cells are resistant to interferon (IFN)-γ–mediated induction of major histocompatibility complex (MHC) class II molecule expression. This suppression of class II MHC induction is considered to be one of the ways in which the eye is able to inhibit inflammatory responses. However, the mechanism(s) of this suppression is unknown. In this study, we have probed the molecular basis of this phenotype and report two distinct mechanisms underlying this phenotype.

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