Hemodynamic Interactions of Verapamil and Isoflurane

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Abstract
The hemodynamic interactions of verapamil an isoflurane were studied in 8 dogs. Left ventricular function was analyzed using a right heart bypass preparation to permit rigid hemodynamic control. Hemodynamic studies were performed at 0.7, 1.05 and 1.40% isoflurane before and during the maintenance of 2 stable levels of verapamil, administered i.v. by combining a bolus dose (0.2 mg .cntdot. kg-1) with an infusion (3.0 and 6.0 .mu.g .cntdot. kg-1 .cntdot. min-1). Isoflurane produced a concentration-dependent depression of left ventricular function as indicated by dP[pressure]/dt max, per cent systolic shortening and left ventricular function curves. This depression was enhanced in a dose-plasma concentration-dependent manner by verapamil and was reversed by CaCl2. Isoflurane alone and the combination of verapamil and isoflurane decreased systemic vascular resistance in a dose-dependent fashion that was antagonized partially by CaCl2. Verapamil can enhance the hemodynamic effects of isoflurane in a dose-related manner that needs to be considered when both drugs are administered together.

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