Paroxysmal Nocturnal Hemoglobinuria with Onset in Childhood and Adolescence
- 3 October 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (14) , 991-996
- https://doi.org/10.1056/nejm199110033251403
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder characterized by hemoglobinuria, thrombosis, infection, and a tendency toward bone marrow aplasia. Onset usually occurs in adulthood. Few children and adolescents with PNH have been described, and data on diagnosis, clinical course, and survival in young patients are unavailable.Keywords
This publication has 35 references indexed in Scilit:
- CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding ProteinScience, 1990
- Relationship between the membrane inhibitor of reactive lysis and the erythrocyte phenotypes of paroxysmal nocturnal hemoglobinuria.Journal of Clinical Investigation, 1989
- Acute myeloblastic leukemia in paroxysmal nocturnal hemoglobinuria. Evidence of evolution from the abnormal paroxysmal nocturnal hemoglobinuria clone.Journal of Clinical Investigation, 1987
- Interactions of the platelets in paroxysmal nocturnal hemoglobinuria with complement. Relationship to defects in the regulation of complement and to platelet survival in vivo.Journal of Clinical Investigation, 1987
- Paroxysmal nocturnal hemoglobinuria. Termination in acute myelomonocytic leukemia and reappearance after leukemic remissionArchives of internal medicine (1960), 1981
- The Population of Cells in Paroxysmal Nocturnal Haemoglobinuria of Intermediate Sensitivity to Complement Lysis: Significance and Mechanism of Increased Immune LysisBritish Journal of Haematology, 1974
- Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody.Journal of Clinical Investigation, 1966
- Neutrophil (Leucocyte) Alkaline Phosphatase in Paroxysmal Nocturnal HaemoglobinuriaBritish Journal of Haematology, 1965
- Paroxysmal Nocturnal Haemoglobinuria: Variation in Clinical Severity and Association with Bone-Marrow HypoplasiaBritish Journal of Haematology, 1961
- Paroxysmale HaemoglobinurieDeutsche Medizinische Wochenschrift (1946), 1882