Nucleation of microtubule assembly by a γ-tubulin-containing ring complex
- 1 December 1995
- journal article
- Published by Springer Nature in Nature
- Vol. 378 (6557) , 578-583
- https://doi.org/10.1038/378578a0
Abstract
The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.Keywords
This publication has 34 references indexed in Scilit:
- The microtubule lattice — dynamic instability of conceptsTrends in Cell Biology, 1995
- THE CENTROSOME AND CELLULAR ORGANIZATIONAnnual Review of Biochemistry, 1994
- γ-Tubulin: the microtubule organizer?Trends in Cell Biology, 1992
- γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosomePublished by Elsevier ,1991
- γ-tubulin is a component of the spindle pole body that is essential for microtubule function in Aspergillus nidulansCell, 1990
- Identification of γ-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulansNature, 1989
- Influence of the centrosome on the structure of nucleated microtubules.The Journal of cell biology, 1985
- Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitroThe Journal of cell biology, 1980
- Microtubule Formation in vitro in Solutions Containing Low Calcium ConcentrationsScience, 1972
- Are Cytoplasmic Microtubules Heteropolymers?Proceedings of the National Academy of Sciences, 1971