Modulation of Help and Suppression in a Hapten-Carrier System
Open Access
- 1 March 1976
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 116 (3) , 600-605
- https://doi.org/10.4049/jimmunol.116.3.600
Abstract
Provision of β-galactosidase (GZ) under defined conditions of dose and time can either help or suppress a subsequent response to trinitrophenyl (TNP)-GZ in CBA/J mice. The optimal helper effect occurs when 107 spleen cells from mice primed 9 or more days previously with 10 µg GZ are adoptively transferred to irradiated recipients which are then challenged with 10 µg TNP50GZ. Optimum suppression results from the transfer of spleen cells from mice primed 3 days previously with 100 µg GZ and challenge of recipients with TNP150GZ. Both help and suppression are carrier-specific and mediated by T cells. In experiments where helper or suppressor cells were mixed with normal cells, the anti-TNP response was proportional to the number of primed cells transferred. The results point to a wave of suppression as the initial event after immunization, which is succeeded by period in which the helper effect dominates.Keywords
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