Positional effect of single bulge nucleotide on PNA(peptide nucleic acid)/DNA hybrid stability

1 November 1999

journal article
Published by Oxford University Press (OUP) in Nucleic Acids Symposium Series

Vol. 42 (1) , 95-96
https://doi.org/10.1093/nass/42.1.95

Abstract

We report positional effect of bulge nucleotide on PNA/DNA hybrid stability. CD spectra showed that PNA/DNA hybrids required at least seven base pairings at a stem region to form a bulged structure. On the other hand, DNA/DNA could form bulged structure when there are only four base pairings adjacent to the bulge nucleotide. We discuss why PNA requests such a many base pairings to form bulged structure from a nearest neighbor standpoint.

Keywords

DNA HYBRID
PNA
NUCLEIC ACID
PEPTIDE NUCLEIC
POSITIONAL EFFECT
EFFECT OF SINGLE
HYBRID STABILITY
SINGLE BULGE

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