Studies on the Synthesis and Antiallergic Activity of 5H-[1]-Benzopyrano [2, 3-b] pyridine Derivatives

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Abstract
A series of hydroxyalkyl, acyloxyalkyl, alkoxy (alkylthio)alkyl, acyl, carboxy or 1H-tetrazol-5-yl substituted 5H-[1]benzopyrano[2,3-b]pyridine derivatives were synthesized by various methods, and the relationship between their structures and inhibitory activities of passive cutaneous anaphylaxis was studied. 9-Chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine administered orally to rats was most potent among the compounds tested.