A genetically diabetic model "KK-CAy mice" for a pharmacological assay.

Publisher Website
Google Scholar
Abstract
A genetically diabetic model, KK-CAy mice which were bred by mating female KK mice (aa, BB, cc) with male KK-CAy mice (Aya, BB, CC), was studied as a tool for a pharmacological assay. Body weights of KK-CAy mice increased more rapidly than those of control mice, KK-C. When the body weights of male KK-CAy mice reached about 30 g 10 wk after birth, their blood glucose levels increased. Severe hyperglycemia (over 300 mg/100 ml) was often observed in the males, but not in the females. Glucose tolerance in the KK-CAy mice was more markedly impaired than that in the control mice. The increase in blood FFA [free fatty acid] level correlated with the increase in body weight on both KK-CAy mice and the controls. When hyperinsulinemia was observed, the ratio of plasma immunoreactive insulin (IRI) level to blood glucose level in the male mice was lower than that seen in the female mice. When hyperglucagonemia was observed, elevation of plasma immunoreactive glucagon (IRG) was more remarkable in the males than in the females. Morphological study showed insular degranulation only in the males. Since the dose-dependent insulin-induced falling was observed on blood glucose level in nonfasted KK-CAy mice, they could be used as a feasible tool for an assay of antidiabetic drugs.

This publication has 1 reference indexed in Scilit: