Effects of Magnesium Sulfate on Renal Function, Electrolyte Excretion and Clearance of Magnesium

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Abstract
The constant intravenous infusion of magnesium sulfate in patients with chronic renal disease produced a significant decrease in renal plasma flow, no change in glomerular filtration rate and no alteration in urinary excretion of sodium, chloride and potassium. Normal men had shown a similar decline in renal plasma flow but also a decrease in glomerular filtration rate, an increase in urinary excretion of sodium and chloride and a decrease in urinary excretion of potassium. The serum concentrations of these electrolytes were not altered in either group. The values for clearance of magnesium in this study were below those required to implicate tubular excretion of this ion. Submitted on October 15, 1956