Ampicillin concentrations in human serum and dental pulp following a single oral administration.
Open Access
- 1 January 1984
- journal article
- Published by Nihon University School of Dentistry in The Journal of Nihon University School of Dentistry
- Vol. 26 (2) , 148-154
- https://doi.org/10.2334/josnusd1959.26.148
Abstract
Twenty-one patients who underwent the extraction of impacted mandibular third molars in a nonfasting state were given a single oral dose of ampicillin (500mg) preoperatively. Specimens of serum (n=21) and dental pulp (n=21) were obtained during the operations and assayed for amplicillin content. The peaks of mean serum and dental pulp ampicillin concentrations were found at an identical time, 120 minutes after administration, which were 2.22μg/ml and 1.38μg/g, respectively. The mean concentration ratio of dental pulp to serum at the peak time was 0.59, which was of a higher ratio than those found in gingiva, mandibular bone and dental follicle.Keywords
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