Follicle Stimulating Activity of Human Chorionic Gonadotropin: Effect of Dissociation and Recombination of Subunits
- 1 October 1976
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 99 (4) , 1126-1128
- https://doi.org/10.1210/endo-99-4-1126
Abstract
The follicle stimulating activity (FSA) and interstitial cell stimulating activity (ICSA) of highly purified human chorionic gonadotropin (hCG), its .alpha. and .beta. subunits, and hCG generated by subunit recombination were determined [in rats] by ovarian weight and ventral prostate weight bioassays. Whereas highly purified hCG exhibited both FSA and ICSA, its separated subunits were essentially devoid of both activities. ICSA and FSA, indistinguishable from that of the highly purified hCG, were restored by recombination of the hCG subunits. These observations are consistent with the hypothesis that the FSA and ICSA found in highly purified hCG preparations are properties of the hCG molecule.This publication has 1 reference indexed in Scilit:
- Follicle stimulation as an intrinsic property of human chorionic gonadotropinThe Anatomical Record, 1967