Respiratory rhythm generation during gasping depends on persistent sodium current
- 12 February 2006
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 9 (3) , 311-313
- https://doi.org/10.1038/nn1650
Abstract
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.Keywords
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