Diastereoselective Synthesis of 1,2-Diamines by Palladium Catalyzed Aza-Claisen Rearrangement
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (07) , 729-734
- https://doi.org/10.1055/s-1993-25930
Abstract
In the thermal rearrangement of allylic trichloroacetimidates 6, no 1, 2-asymmetric induction can be observed. Palladium(II) catalyzed, however, the rearrangement takes place at 25°C and yields diastereoselectively (de ≥ 98%) the anti-1,2-diamines 7. The allylic trichloroacetimidates 6 can easily be prepared starting from α-amino acids.Keywords
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