Proof by synthesis that unrearranged hydroxymethylbilane is the product from deaminase and the substrate for cosynthetase in the biosynthesis of uro'gen-III

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Abstract
The labile unrearranged hydroxymethylbilane (5) is synthesised unambiguously, is proved to be identical with the product from deaminase acting on porphobilinogen, and is shown to be the substrate for deaminase-free cosynthetase which quantitatively ring-closes (5) with rearrangement to uro'gen-III (7).