The photochemistry of lomefloxacin. An aromatic carbene as the key intermediate in photodecomposition
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 14,p. 1329-1330
- https://doi.org/10.1039/a703226i
Abstract
Irradiation of the 6,8-difluoroquinolone antibiotic lomefloxacin causes selective heterolytic defluorination from position 8 and leads to products rationalized as arising from the cation either via nucleophile addition or intramolecular carbene C–H insertion and hydrogen transfer.Keywords
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