Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae
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- 10 October 2000
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 97 (21) , 11383-11390
- https://doi.org/10.1073/pnas.97.21.11383
Abstract
In the yeast Saccharomyces cerevisiae , meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.Keywords
This publication has 37 references indexed in Scilit:
- Meiotic Chromosomes: Integrating Structure and FunctionAnnual Review of Genetics, 1999
- The Transcriptional Program of Sporulation in Budding YeastScience, 1998
- Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic ScaleScience, 1997
- An atypical topoisomerase II from archaea with implications for meiotic recombinationNature, 1997
- Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein FamilyCell, 1997
- The yeast genome project: what did we learn?Trends in Genetics, 1996
- MEIOTIC RECOMBINATION HOTSPOTSAnnual Review of Genetics, 1995
- Meiosis-Induced Double-Strand Break Sites Determined by Yeast Chromatin StructureScience, 1994
- Chromatin organization at meiosisBioEssays, 1988
- A yeast acts in (Cis) to inhibit meiotic gene conversion of adjacent sequencesCell, 1988