ULTRASTRUCTURAL AND BIOCHEMICAL CHANGES IN CULTURED HUMAN MALIGNANT-MELANOMA CELLS AFTER HETEROTRANSPLANTATION INTO NUDE MICE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (9) , 3106-3112
Abstract
Cells from 3 lines of cultured human malignant melanomas were heterotransplanted into nude mice and then recultured. The shape of the cells, the aspect of the melanosomes and the content of 5-S-cysteinyldopa showed pronounced changes induced by transplantation. Such results indicate that this experimental model should be used with great caution. A relationship was found between the shape of the melanosomes and the content of 5-S-cysteinyldopa in the cells.

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