5−Hydroxytryptamine desensitization fails to modify GABA-induced inhibitory responses in the guinea-pig colon
- 1 June 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (6) , 406-408
- https://doi.org/10.1111/j.2042-7158.1984.tb04410.x
Abstract
In segments of guinea-pig colon, treated with 1 μm hyoscine, a 5−HT desensitization procedure that decreased the potency of 5−HT 41−fold in relaxing the longitudinal musculature, failed to modify the non-adrenergic GABA-induced inhibitory responses, suggesting that the action of GABA in this preparation is not 5−HT-mediated. These results are at variance with those obtained in the guinea-pig ileum where 5−HT seems to play a role in GABA-induced cholinergic contractions.Keywords
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