A Hepatitis B Surface Antigen Mutant That Lacks the Antigenic Loop Region Can Self-Assemble and Interact with the Large Hepatitis Delta Antigen
Open Access
- 1 October 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (19) , 10060-10063
- https://doi.org/10.1128/jvi.76.19.10060-10063.2002
Abstract
A novel hepatitis B virus surface antigen mutant harboring a deletion of most of the major antigenic loop region was competent for self-assembly and secretion. Although the mutant protein was competent for interaction with and incorporation of free large hepatitis delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.Keywords
This publication has 8 references indexed in Scilit:
- Limitations to Replication of Hepatitis Delta Virus in Avian CellsJournal of Virology, 2000
- Effect of Mutations in the Small Envelope Protein of Hepatitis B Virus on Assembly and Secretion of Hepatitis Delta VirusVirology, 1998
- The roles of the delta antigen in the structure and replication of hepatitis delta virusJournal of Hepatology, 1991
- Small-form hepatitis B surface antigen is sufficient to help in the assembly of hepatitis delta virus-like particlesJournal of Virology, 1991
- The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus.Proceedings of the National Academy of Sciences, 1991
- Assembly of Hepadnaviral Virions and Subviral ParticlesPublished by Springer Nature ,1991
- Transmission of the hepatitis B virus-associated delta agent to the eastern woodchuck.Proceedings of the National Academy of Sciences, 1984
- delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.Proceedings of the National Academy of Sciences, 1980