Effect of acebutolol and propranolol on premature ventricular complexes
- 1 July 1980
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 28 (1) , 28-31
- https://doi.org/10.1038/clpt.1980.126
Abstract
A double‐blind, randomized study comparing the efficacy of intravenous acebutolol with propranolol on frequent premature ventricular complexes (PVCs) in 24 patients is reported. Frequent PVCs were abolished or reduced by 75% or more in 10 of 12 patients (83%) given acebutolol and in 10 of 12 patients (83%) given propranolol. The therapeutic effect of acebutolol lasted for at least 1 hr in 4 of 12 patients (33%), for at least 3.5 hr in 3 of 12 patients (25%), and for at least 4 hr in 2 of 12 patients (17%). The effect of propranolol lasted for at least 1 hr in 6 of 12 patients (50%), for at least 3.5 hr in 4 of 12 patients (33%), and for at least 4 hr in 4 of 12 patients (33%). Hence, intravenous acebutolol and propranolol were equally effective. Clinical Pharmacology and Therapeutics (1980) 28, 28–31; doi:10.1038/clpt.1980.126This publication has 0 references indexed in Scilit: